Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression
نویسندگان
چکیده
منابع مشابه
Localized Lymph Node Light Chain Amyloidosis
Immunoglobulin-derived light chain amyloidosis can occasionally be associated with localized disease. We present a patient with localized lymph node light chain amyloidosis without an underlying monoclonal protein or lymphoproliferative disorder and review the literature of lymph node amyloidosis discussing work-up and risk factors for systemic progression.
متن کاملkappa/lambda index for confirming urinary free light chain in amyloidosis AL and other plasma cell dyscrasias.
Primary systemic amyloidosis (AL), a disease involving the deposition of immunoglobulin light chains in tissue, is caused by a plasma cell dyscrasia. In the case of amyloidosis reported here, no monoclonal component was seen upon routine protein electrophoresis of serum or urine nor was a bone marrow analysis positive for AL. Immunofixation electrophoresis did not show a typical paraprotein ban...
متن کاملLight Chain Amyloidosis
Light chain (AL) amyloidosis is caused by a usually small plasma-cell clone that is able to produce the amyloidogenic light chains. They are able to misfold and aggregate, deposit in tissues in the form of amyloid fibrils and lead to irreversible organ dysfunction and eventually death if treatment is late or ineffective. Cardiac damage is the most important prognostic determinant. The risk of d...
متن کاملChromosomal location of human kappa and lambda immunoglobulin light chain constant region genes
The chromosomal location of human constant region light chain immunoglobulin (Ig) genes has been determined by analyzing a group of human fibroblast/rodent somatic cell hybrids with nucleic acid probes prepared from cloned human kappa and lambda constant region genes. Human chromosomes in each cell line were identified by isoenzyme analysis. The DNA from hybrid cells was digested with restricti...
متن کاملQuantification of serum free light chain kappa and lambda by the SPAPLUS analyser.
OBJECTIVE Clinical assessment of the SPAPLUS® system for the determination of the serum free light chains kappa (κ FLC) and lambda (λ FLC) compared to the BNII®. DESIGN AND METHODS 126 serum specimens from our routine activity were analysed on two different analysers: the BNII® (immunonephelometry, Siemens) and the SPAPLUS® (turbidimetry, Binding Site). We compared the absolute values of the ...
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ژورنال
عنوان ژورنال: Clinical Endoscopy
سال: 2018
ISSN: 2234-2400,2234-2443
DOI: 10.5946/ce.2017.118